DUCKWORTH, D. MALCOLM: search on Z-Library

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1

Model studies on a synthetically facile series of N-substituted phenyl-N′-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists

Steven M. Bromidge, Steven Dabbs, David T. Davies, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Angela Gadre, Peter Ham, Graham E. Jones, Frank D. King, Damian V. Saunders, Kevin M. Thewlis, D

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 186 KB

english, 1999

2

C-20 configuration in adirubine

Brown, Richard T., Duckworth, D. Malcolm

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1976

Language:

english

File:

PDF, 101 KB

english, 1976

3

Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel

Conrad G. Chapman, Helen J. Meadows, Rob J. Godden, David A. Campbell, Malcolm Duckworth, Rosemary E. Kelsell, Paul R. Murdock, Andrew D. Randall, Gillian I. Rennie, Israel S. Gloger

Journal:

Molecular Brain Research

Year:

2000

Language:

english

File:

PDF, 409 KB

english, 2000

4

The impact of genomics on drug design

Lee J. Beeley, D. Malcolm Duckworth

Journal:

Drug Discovery Today

Year:

1996

Language:

english

File:

PDF, 764 KB

english, 1996

5

Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system

Christopher Larminie, Paul Murdock, Jean-Philippe Walhin, Malcolm Duckworth, Kendall J. Blumer, Mark A. Scheideler, Martine Garnier

Journal:

Molecular Brain Research

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

6

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

Andrew D. Medhurst, Gillian Rennie, Conrad G. Chapman, Helen Meadows, Malcolm D. Duckworth, Rosemary E. Kelsell, Israel I. Gloger, Menelas N. Pangalos

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 2.85 MB

english, 2001

7

Biarylcarbamoylindolines Are Novel and Selective 5-HT 2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

Bromidge, Steven M., Dabbs, Steven, Davies, David T., Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T., Gaster, Laramie M., Ham, Peter, Jones, Graham E., King, Frank D., Mulholland, Keith R., S

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 448 KB

english, 2000

8

Conversion of secologanin into elenolic acid and 18-oxayohimban alkaloids

Brown, Richard T., Chapple, C. Lyn, Duckworth, D. Malcolm, Platt, Ray

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1976

Language:

english

File:

PDF, 337 KB

english, 1976

9

ChemInform Abstract: CONVERSION OF SECOLOGANIN INTO ELENOLIC ACID AND 18-OXAYHIMBAN ALKALOIDS

BROWN, RICHARD T., CHAPPLE, C. LYN, DUCKWORTH, D. MALCOLM, PLATT, RAY

Journal:

Chemischer Informationsdienst

Year:

1976

File:

PDF, 225 KB

1976

10

Co-cyclizations of nitrogen-containing acetylenes induced by a nickel triphenylphosphine complex to give aminoindane, isoindoline and isoindolinone derivatives

Duckworth, D. Malcolm, Lee-Wong, Simon, Slawin, Alexandra M. Z., Smith, Edward H., Williams, David J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 1.07 MB

english, 1996

11

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

Michael R Barnes, D.Malcolm Duckworth, Lee J Beeley

Journal:

Trends in Pharmacological Sciences

Year:

1998

Language:

english

File:

PDF, 712 KB

english, 1998

12

( R )-3, N -Dimethyl- N -[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT 7 Receptor Antagonist

Forbes, Ian T., Dabbs, Steven, Duckworth, D. Malcolm, Jennings, Andrew J., King, Frank D., Lovell, Peter J., Brown, Anthony M., Collin, Lissa, Hagan, Jim J., Middlemiss, Derek N., Riley, Graham J., Th

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 67 KB

english, 1998

13

6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

Bromidge, Steven M., Duckworth, Malcolm, Forbes, Ian T., Ham, Peter, King, Frank D., Thewlis, Kevin M., Blaney, Frank E., Naylor, Christopher B., Blackburn, Thomas P., Kennett, Guy A., Wood, Martyn D.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 131 KB

english, 1997

14

Measurements of environmental 1,3-butadiene with pumped and diffusive samplers using the sorbent Carbopack X

Nicholas A. Martin, Philippa Duckworth, Malcolm H. Henderson, Nigel R.W. Swann, Simon T. Granshaw, Robert P. Lipscombe, Brian A. Goody

Journal:

Atmospheric Environment

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

15

C20orf9-003 (ACI-1), a Gene Localized on Chromosome 20q13.12 Encoding for a 49 kD Cytoplasmic Protein with a Putative Nucleotide Binding Site

Scott, Boyd B., Zaratin, Paola F., Clarke, Geoffrey D., Barnes, Michael R., Murdock, Paul R., Lynch, Frank J., Duckworth, Malcolm

Journal:

DNA Sequence - The Journal of Sequencing and Mapping

Year:

2004

Language:

english

File:

PDF, 502 KB

english, 2004

16

Cloning and Characterization of Human NTT5 and v7-3: Two Orphan Transporters of the Na+/Cl−-Dependent Neurotransmitter Transporter Gene Family

Maurice K. Farmer, Melanie J. Robbins, Andrew D. Medhurst, David A. Campbell, Kathryn Ellington, Malcolm Duckworth, Anthony M. Brown, Derek N. Middlemiss, Gary W. Price, Menelas N. Pangalos

Journal:

Year:

2000

Language:

english

File:

PDF, 571 KB

english, 2000

17

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Philip Hayes, Helen J Meadows, Martin J Gunthorpe, Mark H Harries, D.Malcolm Duckworth, William Cairns, David C Harrison, Catherine E Clarke, Kathryn Ellington, Rab K Prinjha, Amanda J.L Barton, Andre

Journal:

Year:

2000

Language:

english

File:

PDF, 591 KB

english, 2000

18

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors

Lloyd, Katie A., Parsons, Bryony N., Burkitt, Michael D., Moore, Andrew R., Papoutsopoulou, Stamatia, Boyce, Malcolm, Duckworth, Carrie A., Exarchou, Klaire, Howes, Nathan, Rainbow, Lucille, Fang, Yon

Journal:

CMGH Cellular and Molecular Gastroenterology and Hepatology

Year:

2020

File:

PDF, 7.10 MB

2020

19

A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Lovell, Peter J., Bromidge, Steven M., Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T., Jennings, Andrew J., King, Frank D., Middlemiss, Derek N., Rahman, Shirley K., Saunders, Damian V.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 145 KB

english, 2000

20

In silico identification of novel therapeutic targets

D.Malcolm Duckworth, Philippe Sanseau

Journal:

Drug Discovery Today

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

21

Novel and Selective 5-HT 2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Bromidge, Steven M., Dabbs, Steven, Davies, David T., Duckworth, D. Malcolm, Forbes, Ian T., Ham, Peter, Jones, Graham E., King, Frank D., Saunders, Damian V., Starr, Susannah, Thewlis, Kevin M., Wyma

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 260 KB

english, 1998

22

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

Steven M. Bromidge, Steven Dabbs, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Graham E. Jones, Jerome Jones, Frank D. King, Damian V. Saunders, Thomas P. Blackburn, Vicky Holland, Guy A. Kenn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

23

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

Steven M. Bromidge, Susannah Davies, D.Malcolm Duckworth, Ian T. Forbes, Graham E. Jones, Jerome Jones, Frank D. King, Thomas P. Blackburn, Vicky Holland, Guy A. Kennett, Sean Lightowler, Derek N. Mid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

24

Biogenetically patterned synthesis of cadambine

Richard T. Brown, D.Malcolm Duckworth, Cid A.M. Santos

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 147 KB

english, 1991

25

The Selective 5-HT 1B Receptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3- f ]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo

Gaster, Laramie M., Blaney, Frank E., Davies, Susannah, Duckworth, D. Malcolm, Ham, Peter, Jenkins, Sarah, Jennings, Andrew J., Joiner, Graham F., King, Frank D., Mulholland, Keith R., Wyman, Paul A.,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 495 KB

english, 1998

26

Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT 2C/2B Receptor Antagonists

Forbes, Ian T., Dabbs, Steven, Duckworth, D. Malcolm, Ham, Peter, Jones, Graham E., King, Frank D., Saunders, Damian V., Blaney, Frank E., Naylor, Christopher B., Baxter, Gordon S., Blackburn, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 387 KB

english, 1996

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